Spermotile - A sophisticated tool for improved fertilization success rate

Sperm filtration for improved success rate of assisted reproduction technology

About the technology

With current automated or manual IVF methods focusing on motility, the chance of identifying a sperm for fertilization is high, but the likelihood of the selected sperm being the best is small. This means an inaccurate quality analysis that takes a toll on success rate and asks for multiple fertilization attempts.

Spermotile solves this issue by an 'all-rounder' sperm selection criterion that is morphologically healthy, motile and demonstrates desirable dynamic behavior, enabling that the sperms picked are of indeed high quality and highly likely to result into success in the first attempt. In turn, it translated to better throughput and leaner operating costs.

Value proposition

The spermotile is an end-to-end solution for selecting the best sperm automatically in terms of motility, morphology and behavior and performing the fertilization process with improved accuracy, efficiency, and success rate, while simultaneously providing a low-cost, ready to use, and low training option for the end user. Patent pending.

Opportunities for collaboration

  • Development and testing of Spermotile
  • Pilot-testing with customers
Illustrated comparison between Spermotile and current solutions' processing of filtering dead, non-progressive, and haphazard semen to isolate the best quality sperm. Current CASA solutions use phase contrast microscopy (PCM) to identify and analyze sperm, restricting analysis of advanced sperm motility.

Collaborators

University of Tromsø

Contact information

Photo: Marius Fiskum

Lars Sørensen

Business Developer | Tech Transfer

lars @ norinnova .no
Tel. 942 45 511

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New therapeutic for liver disease, NASH

An unmet medical need

Non-alcoholic steatohepatitis (NASH) is an advanced form of fatty liver disease that is expected to become the major cause of liver transplantation in the US by 2025. There is an enormous unmet medical need to treat the disease because of its high prevalence and lack of treatment options: there are currently no approved therapeutics for NASH. We are developing a novel therapeutic based on our unique knowledge of an intercellular pathway associated with NASH.

Areas of application

Over 25% of adults worldwide have non-alcoholic fatty liver, and 10-30% of these people will progress to the more serious disease, NASH. Our therapeutic targets this latter population, who currently have no approved treatment options beyond lifestyle changes.

Advantage

NASH has typically been complicated to treat because there are multiple challenges:

  • fat accumulation
  • inflammation
  • liver scarring

We use our knowledge of intercellular pathways to target all three disease hallmarks for the first time.

Opportunities for Collaboration

Our data in animals and human cells support targeting NASH via a newly-discovered intercellular pathway. We are open to partnering to accelerate pre-clinical and clinical development based on these promising results.

University of Tromsø

Contact information

Photo: Marius Fiskum

Bronwyn Smithies

Business Developer | Tech Transfer

bronwyn @ norinnova .no
Tel. 412 47 420

Read about other projects:

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-
August 11, 2023

A tool that predicts ice amount and distribution on marine structures About the technology Due to climate changes the Arctic marine territories ...

,

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-
August 9, 2023

CYMOPLIVE - Cyto-Motility and Cyto-Plasticity in Vitro Live-Cell Assay About the technology Cymoplive is a platform that allows us to study cells ...

, ,

SMOLTR - Synchronizing seawater readiness of salmon smolt with seawater transfer

-
May 12, 2023

About the technology SMOLTR is a smolt-verification tool to be utilized in the smoltification process of salmon. Data indicates that this technology ...

PsyXpress, a unique protein expression platform

-
May 3, 2023

- Based on the Aliivibrio wodanis chassis (PsyXpress) The challenge The main challenge in protein production is to achieve optimal solubility, activity ...

Single-objective light-sheet imaging system (SOLIS)

-
May 3, 2023

Instant volume microscopy The SOLIS Microscope A new type of fluorescence microscope that combines the best aspects of confocal with light-sheet microscopy. SOLIS ...

, , ,

Microstructured Air-Suspended Thin-film (MAST) waveguide sensor

-
May 3, 2023

Superior gas monitoring and measurement Industry challenges Traditional gas sensing with absorption spectroscopy uses large multi-pass cells containing a sample gas, through ...

,