An unmet medical need

Non-alcoholic steatohepatitis (NASH) is an advanced form of fatty liver disease that is expected to become the major cause of liver transplantation in the US by 2025. There is an enormous unmet medical need to treat the disease because of its high prevalence and lack of treatment options: there are currently no approved therapeutics for NASH.

Impact

Over 25% of adults worldwide have non-alcoholic fatty liver, and 10-30% of these people will progress to the more serious disease, NASH. Beyond lifestyle changes, there are no FDA approved therapeutic treatments for NASH.

The invention

We have a novel therapeutic approach to NASH based on a new understanding of disease-causing signaling pathways in the liver. Our approach reduces all 3 hallmarks of disease:

  • fat accumulation
  • fibrosis (liver scarring)
  • inflammation
Plan and commercial strategy

The project is currently supported by the Research Council of Norway, Novo Nordisk Foundation, and UiT – The Arctic University of Norway. Upon generation of proof-of-concept data, we plan to continue pre-clinical and clinical development through a spin-off company. We are seeking collaborations with the right partners to bring the project forward into pre-clinical and clinical development, including:

  • industry collaborations and partnerships
  • investors
Image: Treatment resulted in 41-58% reduction in all 3 disease characteristics in NASH mice.

Partners and collaborators

Contact information

Foto: Marius Fiskum

Bronwyn Smithies

Business Developer | Tech Transfer

bronwyn@norinnova.no
Tel. 412 47 420

Read about other projects:

mSpider

Motivating continous Sharing of Physical activity using non-Intrusive Data Extraction methods Retro- and prospectively About the technology Data collection of physical data …

Thyroid Assist

– A novel decision support aid tool (DST) for optimal levothyroxine dosage after thyroidectomy About the technology Levothyroxine is a necessary synthetic …

About the technology New and advanced label-free and super resolution microscopes and nanoscopes have emerged, and their characterization is becoming more demanding. …

Nanospacer

– Bringing nanofluidic technology to the people About the technology The Nanospacer is a specially designed microscope coverslip that allows nanoscale particle …

A tool that predicts ice amount and distribution on marine structures About the technology Due to climate changes the Arctic marine territories …

CYMOPLIVE – Cyto-Motility and Cyto-Plasticity in Vitro Live-Cell Assay About the technology Cymoplive is a platform that allows us to study cells …