– MicroRNAs for risk assessment and treatment of venous thromboembolism
The challenge
Venous thromboembolism (VTE) is a highly prevalent disease, affecting around 1.1 million individuals in Europe each year, with 540,000 associated deaths. No modifiable risk-factors have been identified yet. The current anti-coagulant treatment is associated with serious bleeding risks. We therefore need to find a drug that prevents VTE without serious side affects.
Our approach
- Specific microRNAs associated with a higher risk of VTE were found
- Targeted intervention of these microRNAs has the potential to effectively prevent VTE
- Treatment of VTE with microRNA therapeutic without bleeding risk
Opportunities for Collaboration
- Searching for a collaborative R&D deal with industrial partner
- Looking for a pharmaceutical partner with the expertise, commitment and financial strength to take it through the clinical phase and into the market.
Results
- Population study
A pilot and a validation study show that specific miRNAs can be potential predictors of VTE and the risk of VTE is highly associated with miRNA level.
- In-vivo mouse model for venous thrombosis
The addition of a specific miRNA show reduction in thrombose size in a in-vivo mouse model
- Patent application for the technology is filed
Collaboration partners
Contact information
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