Single-objective light-sheet imaging system (SOLIS)

Instant volume microscopy

The SOLIS Microscope

A new type of fluorescence microscope that combines the best aspects of confocal with light-sheet microscopy. SOLIS efficiently removes parasitic light from out-of-focus planes that would bleed through between adjacent focal planes and degrade image contrast. 

SOLIS is posed to fill this technology gap between methods that offer the required speed and gentleness on the one hand, and usability and resolution on the other. A prototype has been successfully demonstrated and the technology has patent pending.

 

Value proposition

Being able to observe these tiny, yet fast, cell constituents in their natural environment would provide completely new insights into cellular function and potential starting points for cures of a whole range of diseases.

Opportunities for Collaboration

  • We are currently looking for commercial partners for licensing of the technology. 
Illustration of the SOLIS microscope. (a) Depicted in purple is the scanned oblique light-sheet path; green is the detection path over a multi-plane optical element onto a synchronised rolling shutter camera that consolidates the light paths through the sample volume, instantly producing a high-resolution volumetric image without parasitic light. (b) Conventional widefield and SOLIS images of mitochondria within human heart tissue. Virtually all parasitic out-of-focus light is removed by SOLIS and all z-planes were acquired simultaneously within 100 ms. Depth is colour coded.
Collaborators
Universitetet i Tromsø

Contact information

Foto: Marius Fiskum

Lars Sørensen

Forretningsutvikler | Tech Transfer

lars@norinnova.no
Tlf. 942 45 511

Les om andre prosjekter:

SMOLTR – Synchronizing seawater readiness of salmon smolt with seawater transfer

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12. mai 2023

About the technology SMOLTR is a smolt-verification tool to be utilized in the smoltification process of salmon. Data indicates that this technology …

PsyXpress, a unique protein expression platform

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3. mai 2023

– Based on the Aliivibrio wodanis chassis (PsyXpress) The challenge The main challenge in protein production is to achieve optimal solubility, activity …

Single-objective light-sheet imaging system (SOLIS)

•
3. mai 2023

Instant volume microscopy The SOLIS Microscope A new type of fluorescence microscope that combines the best aspects of confocal with light-sheet microscopy. SOLIS …

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Microstructured Air-Suspended Thin-film (MAST) waveguide sensor

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3. mai 2023

Superior gas monitoring and measurement Industry challenges Traditional gas sensing with absorption spectroscopy uses large multi-pass cells containing a sample gas, through …

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MUSICAL – Multiple Signal Classification Algorithms

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3. mai 2023

– Multi-option distributed computing solutions for super-resolution imaging The MUSICAL technology MUSICAL is an imaging software that makes super-resolution optical microscopy available …

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Spermotile – A sophisticated tool for improved fertilization success rate

•
27. april 2023

Sperm filtration for improved success rate of assisted reproduction technology About the technology With current automated or manual IVF methods focusing on …

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Spermotile – A sophisticated tool for improved fertilization success rate

Sperm filtration for improved success rate of assisted reproduction technology

About the technology

With current automated or manual IVF methods focusing on motility, the chance of identifying a sperm for fertilization is high, but the likelihood of the selected sperm being the best is small. This means an inaccurate quality analysis that takes a toll on success rate and asks for multiple fertilization attempts.

Spermotile solves this issue by an ‘all-rounder’ sperm selection criterion that is morphologically healthy, motile and demonstrates desirable dynamic behavior, enabling that the sperms picked are of indeed high quality and highly likely to result into success in the first attempt. In turn, it translated to better throughput and leaner operating costs.

Value proposition

The spermotile is an end-to-end solution for selecting the best sperm automatically in terms of motility, morphology and behavior and performing the fertilization process with improved accuracy, efficiency, and success rate, while simultaneously providing a low-cost, ready to use, and low training option for the end user. Patent pending.

Opportunities for collaboration

  • Development and testing of Spermotile
  • Pilot-testing with customers
Illustrated comparison between Spermotile and current solutions’ processing of filtering dead, non-progressive, and haphazard semen to isolate the best quality sperm. Current CASA solutions use phase contrast microscopy (PCM) to identify and analyse sperm, restricting analysis of advanced sperm motility.

Collaborators

Universitetet i Tromsø

Contact information

Foto: Marius Fiskum

Lars Sørensen

Forretningsutvikler | Tech Transfer

lars@norinnova.no
Tlf. 942 45 511

Les om andre prosjekter:

SMOLTR – Synchronizing seawater readiness of salmon smolt with seawater transfer

•
12. mai 2023

About the technology SMOLTR is a smolt-verification tool to be utilized in the smoltification process of salmon. Data indicates that this technology …

PsyXpress, a unique protein expression platform

•
3. mai 2023

– Based on the Aliivibrio wodanis chassis (PsyXpress) The challenge The main challenge in protein production is to achieve optimal solubility, activity …

Single-objective light-sheet imaging system (SOLIS)

•
3. mai 2023

Instant volume microscopy The SOLIS Microscope A new type of fluorescence microscope that combines the best aspects of confocal with light-sheet microscopy. SOLIS …

, , ,

Microstructured Air-Suspended Thin-film (MAST) waveguide sensor

•
3. mai 2023

Superior gas monitoring and measurement Industry challenges Traditional gas sensing with absorption spectroscopy uses large multi-pass cells containing a sample gas, through …

,

MUSICAL – Multiple Signal Classification Algorithms

•
3. mai 2023

– Multi-option distributed computing solutions for super-resolution imaging The MUSICAL technology MUSICAL is an imaging software that makes super-resolution optical microscopy available …

, ,

Spermotile – A sophisticated tool for improved fertilization success rate

•
27. april 2023

Sperm filtration for improved success rate of assisted reproduction technology About the technology With current automated or manual IVF methods focusing on …

, , ,

New therapeutic for liver disease, NASH

An unmet medical need

Non-alcoholic steatohepatitis (NASH) is an advanced form of fatty liver disease that is expected to become the major cause of liver transplantation in the US by 2025. There is an enormous unmet medical need to treat the disease because of its high prevalence and lack of treatment options: there are currently no approved therapeutics for NASH. We are developing a novel therapeutic based on our unique knowledge of an intercellular pathway associated with NASH.

Areas of application

Over 25% of adults worldwide have non-alcoholic fatty liver, and 10-30% of these people will progress to the more serious disease, NASH. Our therapeutic targets this latter population, who currently have no approved treatment options beyond lifestyle changes.

Advantage

NASH has typically been complicated to treat because there are multiple challenges:

  • fat accumulation
  • inflammation
  • liver scarring

We use our knowledge of intercellular pathways to target all three disease hallmarks for the first time.

Opportunities for Collaboration

Our data in animals and human cells support targeting NASH via a newly-discovered intercellular pathway. We are open to partnering to accelerate pre-clinical and clinical development based on these promising results.

Universitetet i Tromsø

Contact information

Foto: Marius Fiskum

Bronwyn Smithies

Forretningsutvikler | Tech Transfer

bronwyn@norinnova.no
Tlf. 412 47 420

Les om andre prosjekter:

SMOLTR – Synchronizing seawater readiness of salmon smolt with seawater transfer

•
12. mai 2023

About the technology SMOLTR is a smolt-verification tool to be utilized in the smoltification process of salmon. Data indicates that this technology …

PsyXpress, a unique protein expression platform

•
3. mai 2023

– Based on the Aliivibrio wodanis chassis (PsyXpress) The challenge The main challenge in protein production is to achieve optimal solubility, activity …

Single-objective light-sheet imaging system (SOLIS)

•
3. mai 2023

Instant volume microscopy The SOLIS Microscope A new type of fluorescence microscope that combines the best aspects of confocal with light-sheet microscopy. SOLIS …

, , ,

Microstructured Air-Suspended Thin-film (MAST) waveguide sensor

•
3. mai 2023

Superior gas monitoring and measurement Industry challenges Traditional gas sensing with absorption spectroscopy uses large multi-pass cells containing a sample gas, through …

,

MUSICAL – Multiple Signal Classification Algorithms

•
3. mai 2023

– Multi-option distributed computing solutions for super-resolution imaging The MUSICAL technology MUSICAL is an imaging software that makes super-resolution optical microscopy available …

, ,

Spermotile – A sophisticated tool for improved fertilization success rate

•
27. april 2023

Sperm filtration for improved success rate of assisted reproduction technology About the technology With current automated or manual IVF methods focusing on …

, , ,

MicroRNAs for reduced bleeding risk in Venous thromboembolism patients

– MicroRNAs for risk assessment and treatment of venous thromboembolism

The challenge

Venous thromboembolism (VTE) is a highly prevalent disease, affecting around 1.1 million individuals in Europe each year, with 540,000 associated deaths. No modifiable risk-factors have been identified yet. The current anti-coagulant treatment is associated with serious bleeding risks. We therefore need to find a drug that prevents VTE without serious side affects.

Our approach

  •  Specific microRNAs associated with a higher risk of VTE were found
  • Targeted intervention of these microRNAs has the potential to effectively prevent VTE
  • Treatment of VTE with microRNA therapeutic without bleeding risk

Opportunities for Collaboration​

  • Searching for a collaborative R&D deal with industrial partner
  • Looking for a pharmaceutical partner with the expertise, commitment and financial strength to take it through the clinical phase and into the market.

Results

  • Population study

A pilot and a validation study show that specific miRNAs can be potential predictors of VTE and the risk of VTE is highly associated with miRNA level.

  • In-vivo mouse model for venous thrombosis

The addition of a specific miRNA show reduction in thrombose size in a in-vivo mouse model

  • Patent application for the technology is filed
Figure: VTE is a serious and common disease, 40% of cases accors spontanously with unknown cause.

Collaboration partners

Universitetet i Tromsø
norinnova logo. Ikon.

Contact information

Foto: Marius Fiskum / www.mariusfiskum.no

Morten Elde

Forretningsutvikler | Tech Transfer

morten@norinnova.no
Tlf. 414 06 762

Les om andre prosjekter:

SMOLTR – Synchronizing seawater readiness of salmon smolt with seawater transfer

•
12. mai 2023

About the technology SMOLTR is a smolt-verification tool to be utilized in the smoltification process of salmon. Data indicates that this technology …

PsyXpress, a unique protein expression platform

•
3. mai 2023

– Based on the Aliivibrio wodanis chassis (PsyXpress) The challenge The main challenge in protein production is to achieve optimal solubility, activity …

Single-objective light-sheet imaging system (SOLIS)

•
3. mai 2023

Instant volume microscopy The SOLIS Microscope A new type of fluorescence microscope that combines the best aspects of confocal with light-sheet microscopy. SOLIS …

, , ,

Microstructured Air-Suspended Thin-film (MAST) waveguide sensor

•
3. mai 2023

Superior gas monitoring and measurement Industry challenges Traditional gas sensing with absorption spectroscopy uses large multi-pass cells containing a sample gas, through …

,

MUSICAL – Multiple Signal Classification Algorithms

•
3. mai 2023

– Multi-option distributed computing solutions for super-resolution imaging The MUSICAL technology MUSICAL is an imaging software that makes super-resolution optical microscopy available …

, ,

Spermotile – A sophisticated tool for improved fertilization success rate

•
27. april 2023

Sperm filtration for improved success rate of assisted reproduction technology About the technology With current automated or manual IVF methods focusing on …

, , ,