An unmet medical need
Non-alcoholic steatohepatitis (NASH) is an advanced form of fatty liver disease that is expected to become the major cause of liver transplantation in the US by 2025. There is an enormous unmet medical need to treat the disease because of its high prevalence and lack of treatment options: there are currently no approved therapeutics for NASH. We are developing a novel therapeutic based on our unique knowledge of an intercellular pathway associated with NASH.
Over 25% of adults worldwide have non-alcoholic fatty liver, and 10-30% of these people will progress to the more serious disease, NASH. Our therapeutic targets this latter population, who currently have no approved treatment options beyond lifestyle changes.
Advantage
NASH has typically been complicated to treat because there are multiple challenges:
- fat accumulation
- inflammation
- liver scarring
We use our knowledge of intercellular pathways to target all three disease hallmarks for the first time.
Opportunities for Collaboration
Our data in animals and human cells support targeting NASH via a newly-discovered intercellular pathway. We are open to partnering to accelerate pre-clinical and clinical development based on these promising results.
Contact information
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