Single-objective light-sheet imaging system (SOLIS)

Instant volume microscopy

The SOLIS Microscope

A new type of fluorescence microscope that combines the best aspects of confocal with light-sheet microscopy. SOLIS efficiently removes parasitic light from out-of-focus planes that would bleed through between adjacent focal planes and degrade image contrast. 

SOLIS is posed to fill this technology gap between methods that offer the required speed and gentleness on the one hand, and usability and resolution on the other. A prototype has been successfully demonstrated and the technology has patent pending.

 

Value proposition

Being able to observe these tiny, yet fast, cell constituents in their natural environment would provide completely new insights into cellular function and potential starting points for cures of a whole range of diseases.

Opportunities for Collaboration

  • We are currently looking for commercial partners for licensing of the technology. 
Illustration of the SOLIS microscope. (a) Depicted in purple is the scanned oblique light-sheet path; green is the detection path over a multi-plane optical element onto a synchronised rolling shutter camera that consolidates the light paths through the sample volume, instantly producing a high-resolution volumetric image without parasitic light. (b) Conventional widefield and SOLIS images of mitochondria within human heart tissue. Virtually all parasitic out-of-focus light is removed by SOLIS and all z-planes were acquired simultaneously within 100 ms. Depth is colour coded.
Collaborators
Universitetet i Tromsø

Contact information

Foto: Marius Fiskum

Lars Sørensen

Forretningsutvikler | Tech Transfer

lars@norinnova.no
Tlf. 942 45 511

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Single-objective light-sheet imaging system (SOLIS)

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Microstructured Air-Suspended Thin-film (MAST) waveguide sensor

Superior gas monitoring and measurement

Industry challenges

Traditional gas sensing with absorption spectroscopy uses large multi-pass cells containing a sample gas, through which a light beam is reflected several times. These are bulky and require large volumes of the sample gas. Therefore, current technology is not compatible with use in small spaces or remote applications, such as drone-assisted environmental monitoring, mining or aerospace applications. 

Additionally, traditional devices cannot be used if only a small amount of sample is available or when small volumes are required for safety reasons (e.g., monitoring toxic substances).

Our solution

We are developing a MAST waveguide sensor for chip-based spectroscopic trace gas sensing. The waveguide is incorporated into a gas sensor chip, forming an on-chip sensing system that enables a drastic reduction on the size, weight of the instrument, and the necessary sample volume compared with current state-of-the-art gas sensors.

It is also the first on-chip sensor that differentiate between isotopes in a sample. As a commercial unit, it will have considerably lower cost and energy consumption than bulk-optics competitors.

 

The MAST waveguide is incorporated into a gas sensor chip, forming an on-chip sensing system.
The MAST waveguide gas sensor combines the sensitivity and performance of bulk optics with the size advantage of chip-based designs.

Collaboration opportunities

We are currently exploring potential applications and seeking partners for development and licensing.

Partners

Universitetet i Tromsø
image (5)
TFS_FARGE_NOR-HOR

Contact information

Foto: Marius Fiskum

Bronwyn Smithies

Forretningsutvikler | Tech Transfer

bronwyn@norinnova.no
Tlf. 412 47 420

Les om andre prosjekter:

SMOLTR – Synchronizing seawater readiness of salmon smolt with seawater transfer

•
12. mai 2023

About the technology SMOLTR is a smolt-verification tool to be utilized in the smoltification process of salmon. Data indicates that this technology …

PsyXpress, a unique protein expression platform

•
3. mai 2023

– Based on the Aliivibrio wodanis chassis (PsyXpress) The challenge The main challenge in protein production is to achieve optimal solubility, activity …

Single-objective light-sheet imaging system (SOLIS)

•
3. mai 2023

Instant volume microscopy The SOLIS Microscope A new type of fluorescence microscope that combines the best aspects of confocal with light-sheet microscopy. SOLIS …

, , ,

Microstructured Air-Suspended Thin-film (MAST) waveguide sensor

•
3. mai 2023

Superior gas monitoring and measurement Industry challenges Traditional gas sensing with absorption spectroscopy uses large multi-pass cells containing a sample gas, through …

,

MUSICAL – Multiple Signal Classification Algorithms

•
3. mai 2023

– Multi-option distributed computing solutions for super-resolution imaging The MUSICAL technology MUSICAL is an imaging software that makes super-resolution optical microscopy available …

, ,

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•
27. april 2023

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Tau-on-Chip: nanofluidic amyloid aggregation within seconds

– Nanofluidic amyloid aggregation within seconds

About the technology

On-demand production of protein aggregates: We produce oligomers and fibrils within seconds in a nanofluidic environment. This has potential for high throughput screening of drug candidates, automated in-vitro assays, and binding assays with single molecule sensitivity.

Areas of application

We envisage producing the nanofluidic Tau-on- Chip devices for use in drug development, clinical trials, research, and protein production.

Value proposition

  • Single molecule sensitivity.
  • For use in drug development, clinical trials, research, and protein production.
  • Patent pending.
Bilde microfluidic
Image: Microfluidic chips fabricated on glass slides.
Image: Induced fibrillation and oligomerization events in seconds.

Opportunities for Collaboration

We are looking for industry partners for collaboration and licensing. We are open to working together on the development of our Tau-on-Chip technology to accomodate your needs.

Resources and partners

Universitetet i Tromsø

Contact information

Foto: Marius Fiskum

Ellen Dybdahl

Forretningsutvikler | Tech Transfer

ellen@norinnova.no
Tlf. 974 79 260

Les om andre prosjekter:

SMOLTR – Synchronizing seawater readiness of salmon smolt with seawater transfer

•
12. mai 2023

About the technology SMOLTR is a smolt-verification tool to be utilized in the smoltification process of salmon. Data indicates that this technology …

PsyXpress, a unique protein expression platform

•
3. mai 2023

– Based on the Aliivibrio wodanis chassis (PsyXpress) The challenge The main challenge in protein production is to achieve optimal solubility, activity …

Single-objective light-sheet imaging system (SOLIS)

•
3. mai 2023

Instant volume microscopy The SOLIS Microscope A new type of fluorescence microscope that combines the best aspects of confocal with light-sheet microscopy. SOLIS …

, , ,

Microstructured Air-Suspended Thin-film (MAST) waveguide sensor

•
3. mai 2023

Superior gas monitoring and measurement Industry challenges Traditional gas sensing with absorption spectroscopy uses large multi-pass cells containing a sample gas, through …

,

MUSICAL – Multiple Signal Classification Algorithms

•
3. mai 2023

– Multi-option distributed computing solutions for super-resolution imaging The MUSICAL technology MUSICAL is an imaging software that makes super-resolution optical microscopy available …

, ,

Spermotile – A sophisticated tool for improved fertilization success rate

•
27. april 2023

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, , ,