Single-objective light-sheet imaging system (SOLIS)

Instant volume microscopy

The SOLIS Microscope

A new type of fluorescence microscope that combines the best aspects of confocal with light-sheet microscopy. SOLIS efficiently removes parasitic light from out-of-focus planes that would bleed through between adjacent focal planes and degrade image contrast. 

SOLIS is posed to fill this technology gap between methods that offer the required speed and gentleness on the one hand, and usability and resolution on the other. A prototype has been successfully demonstrated and the technology has patent pending.

 

Value proposition

Being able to observe these tiny, yet fast, cell constituents in their natural environment would provide completely new insights into cellular function and potential starting points for cures of a whole range of diseases.

Opportunities for Collaboration

  • We are currently looking for commercial partners for licensing of the technology. 
Illustration of the SOLIS microscope. (a) Depicted in purple is the scanned oblique light-sheet path; green is the detection path over a multi-plane optical element onto a synchronised rolling shutter camera that consolidates the light paths through the sample volume, instantly producing a high-resolution volumetric image without parasitic light. (b) Conventional widefield and SOLIS images of mitochondria within human heart tissue. Virtually all parasitic out-of-focus light is removed by SOLIS and all z-planes were acquired simultaneously within 100 ms. Depth is colour coded.
Collaborators
Universitetet i Tromsø

Contact information

Foto: Marius Fiskum

Lars Sørensen

Forretningsutvikler | Tech Transfer

lars@norinnova.no
Tlf. 942 45 511

Les om andre prosjekter:

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3. mai 2023

– Based on the Aliivibrio wodanis chassis (PsyXpress) The challenge The main challenge in protein production is to achieve optimal solubility, activity …

Single-objective light-sheet imaging system (SOLIS)

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3. mai 2023

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MUSICAL – Multiple Signal Classification Algorithms

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MUSICAL – Multiple Signal Classification Algorithms

- Multi-option distributed computing solutions for super-resolution imaging

The MUSICAL technology

MUSICAL is an imaging software that makes super-resolution optical microscopy available to specialized labs and clinics as a high-end premium GPU or embedded solution, or to laymans with their own personal microscopy data through an budget-conscious cloud solution.

The technology can be applied to both super-resolution microscopy raw data as well as data generated by conventional low-cost microscopes. The key advantage it provides is not needing any calibration in illumination engineered microscopes or special dyes for achieving super-resolution.

MUSICAL processing method to exploit the high spatial frequencies of illumination pattern to generate super-resolved image. In other words, processing super-resolution images from microscopes at an immense speed.

The MUSICAL solutions

  • Cloud solution (Beta-stage)

Lightweight software for super-resolution imaging tailored to low-cost microscopes.

  • GPU solution (under development)

Plug-and-play dongle providing state-of-the-art imaging with an additional edge in processing time

  • Embedded solution (to be developed)

MUSICAL as a built-in hardware solution with the microscope. Unlocking it’s full imaging capabilities

Opportunities for collaboration

  • Licensees for MUSICAL cloud solution
  • Collaborative R&D with industrial partner for MUSICAL GPU or MUSICAL Embedded solution
  • Patent pending
As compared to diffraction-limited image on the left, MUSICAL reconstructs the cristae (i.e., the empty spaces between the outer and inner membranes of mitochondria) with amazing number of details using only 100 images of diffraction-limited video.

Collaboration partners

Universitetet i Tromsø

Contact information

Foto: Marius Fiskum

Lars Sørensen

Forretningsutvikler | Tech Transfer

lars@norinnova.no
Tlf. 942 45 511

Les om andre prosjekter:

SMOLTR – Synchronizing seawater readiness of salmon smolt with seawater transfer

•
12. mai 2023

About the technology SMOLTR is a smolt-verification tool to be utilized in the smoltification process of salmon. Data indicates that this technology …

PsyXpress, a unique protein expression platform

•
3. mai 2023

– Based on the Aliivibrio wodanis chassis (PsyXpress) The challenge The main challenge in protein production is to achieve optimal solubility, activity …

Single-objective light-sheet imaging system (SOLIS)

•
3. mai 2023

Instant volume microscopy The SOLIS Microscope A new type of fluorescence microscope that combines the best aspects of confocal with light-sheet microscopy. SOLIS …

, , ,

Microstructured Air-Suspended Thin-film (MAST) waveguide sensor

•
3. mai 2023

Superior gas monitoring and measurement Industry challenges Traditional gas sensing with absorption spectroscopy uses large multi-pass cells containing a sample gas, through …

,

MUSICAL – Multiple Signal Classification Algorithms

•
3. mai 2023

– Multi-option distributed computing solutions for super-resolution imaging The MUSICAL technology MUSICAL is an imaging software that makes super-resolution optical microscopy available …

, ,

Spermotile – A sophisticated tool for improved fertilization success rate

•
27. april 2023

Sperm filtration for improved success rate of assisted reproduction technology About the technology With current automated or manual IVF methods focusing on …

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Spermotile – A sophisticated tool for improved fertilization success rate

Sperm filtration for improved success rate of assisted reproduction technology

About the technology

With current automated or manual IVF methods focusing on motility, the chance of identifying a sperm for fertilization is high, but the likelihood of the selected sperm being the best is small. This means an inaccurate quality analysis that takes a toll on success rate and asks for multiple fertilization attempts.

Spermotile solves this issue by an ‘all-rounder’ sperm selection criterion that is morphologically healthy, motile and demonstrates desirable dynamic behavior, enabling that the sperms picked are of indeed high quality and highly likely to result into success in the first attempt. In turn, it translated to better throughput and leaner operating costs.

Value proposition

The spermotile is an end-to-end solution for selecting the best sperm automatically in terms of motility, morphology and behavior and performing the fertilization process with improved accuracy, efficiency, and success rate, while simultaneously providing a low-cost, ready to use, and low training option for the end user. Patent pending.

Opportunities for collaboration

  • Development and testing of Spermotile
  • Pilot-testing with customers
Illustrated comparison between Spermotile and current solutions’ processing of filtering dead, non-progressive, and haphazard semen to isolate the best quality sperm. Current CASA solutions use phase contrast microscopy (PCM) to identify and analyse sperm, restricting analysis of advanced sperm motility.

Collaborators

Universitetet i Tromsø

Contact information

Foto: Marius Fiskum

Lars Sørensen

Forretningsutvikler | Tech Transfer

lars@norinnova.no
Tlf. 942 45 511

Les om andre prosjekter:

SMOLTR – Synchronizing seawater readiness of salmon smolt with seawater transfer

•
12. mai 2023

About the technology SMOLTR is a smolt-verification tool to be utilized in the smoltification process of salmon. Data indicates that this technology …

PsyXpress, a unique protein expression platform

•
3. mai 2023

– Based on the Aliivibrio wodanis chassis (PsyXpress) The challenge The main challenge in protein production is to achieve optimal solubility, activity …

Single-objective light-sheet imaging system (SOLIS)

•
3. mai 2023

Instant volume microscopy The SOLIS Microscope A new type of fluorescence microscope that combines the best aspects of confocal with light-sheet microscopy. SOLIS …

, , ,

Microstructured Air-Suspended Thin-film (MAST) waveguide sensor

•
3. mai 2023

Superior gas monitoring and measurement Industry challenges Traditional gas sensing with absorption spectroscopy uses large multi-pass cells containing a sample gas, through …

,

MUSICAL – Multiple Signal Classification Algorithms

•
3. mai 2023

– Multi-option distributed computing solutions for super-resolution imaging The MUSICAL technology MUSICAL is an imaging software that makes super-resolution optical microscopy available …

, ,

Spermotile – A sophisticated tool for improved fertilization success rate

•
27. april 2023

Sperm filtration for improved success rate of assisted reproduction technology About the technology With current automated or manual IVF methods focusing on …

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Tau-on-Chip: nanofluidic amyloid aggregation within seconds

– Nanofluidic amyloid aggregation within seconds

About the technology

On-demand production of protein aggregates: We produce oligomers and fibrils within seconds in a nanofluidic environment. This has potential for high throughput screening of drug candidates, automated in-vitro assays, and binding assays with single molecule sensitivity.

Areas of application

We envisage producing the nanofluidic Tau-on- Chip devices for use in drug development, clinical trials, research, and protein production.

Value proposition

  • Single molecule sensitivity.
  • For use in drug development, clinical trials, research, and protein production.
  • Patent pending.
Bilde microfluidic
Image: Microfluidic chips fabricated on glass slides.
Image: Induced fibrillation and oligomerization events in seconds.

Opportunities for Collaboration

We are looking for industry partners for collaboration and licensing. We are open to working together on the development of our Tau-on-Chip technology to accomodate your needs.

Resources and partners

Universitetet i Tromsø

Contact information

Foto: Marius Fiskum

Ellen Dybdahl

Forretningsutvikler | Tech Transfer

ellen@norinnova.no
Tlf. 974 79 260

Les om andre prosjekter:

SMOLTR – Synchronizing seawater readiness of salmon smolt with seawater transfer

•
12. mai 2023

About the technology SMOLTR is a smolt-verification tool to be utilized in the smoltification process of salmon. Data indicates that this technology …

PsyXpress, a unique protein expression platform

•
3. mai 2023

– Based on the Aliivibrio wodanis chassis (PsyXpress) The challenge The main challenge in protein production is to achieve optimal solubility, activity …

Single-objective light-sheet imaging system (SOLIS)

•
3. mai 2023

Instant volume microscopy The SOLIS Microscope A new type of fluorescence microscope that combines the best aspects of confocal with light-sheet microscopy. SOLIS …

, , ,

Microstructured Air-Suspended Thin-film (MAST) waveguide sensor

•
3. mai 2023

Superior gas monitoring and measurement Industry challenges Traditional gas sensing with absorption spectroscopy uses large multi-pass cells containing a sample gas, through …

,

MUSICAL – Multiple Signal Classification Algorithms

•
3. mai 2023

– Multi-option distributed computing solutions for super-resolution imaging The MUSICAL technology MUSICAL is an imaging software that makes super-resolution optical microscopy available …

, ,

Spermotile – A sophisticated tool for improved fertilization success rate

•
27. april 2023

Sperm filtration for improved success rate of assisted reproduction technology About the technology With current automated or manual IVF methods focusing on …

, , ,